FixedSequenceCellCycleModel.cpp

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#include "FixedSequenceCellCycleModel.hpp"
#include "Exception.hpp"
#include "StemCellProliferativeType.hpp"
#include "TransitCellProliferativeType.hpp"
#include "DifferentiatedCellProliferativeType.hpp"
#include "CellCycleTimesGenerator.hpp"
 
FixedSequenceCellCycleModel::FixedSequenceCellCycleModel()
    : ExponentialG1GenerationalCellCycleModel()
{
      mStemCellG1Duration = mTransitCellG1Duration;
}
 
FixedSequenceCellCycleModel::FixedSequenceCellCycleModel(const FixedSequenceCellCycleModel& rModel)
   :  ExponentialG1GenerationalCellCycleModel(rModel)
{
    /*
     * Set each member variable of the new cell-cycle model that inherits
     * its value from the parent.
     *
     * Note 1: some of the new cell-cycle model's member variables will already
     * have been correctly initialized in its constructor or parent classes.
     *
     * Note 2: one or more of the new cell-cycle model's member variables
     * may be set/overwritten as soon as InitialiseDaughterCell() is called on
     * the new cell-cycle model.
     *
     * Note 3: Only set the variables defined in this class. Variables defined
     * in parent classes will be defined there.
     *
     */
}
 
AbstractCellCycleModel* FixedSequenceCellCycleModel::CreateCellCycleModel()
{
    return new FixedSequenceCellCycleModel(*this);
}
 
void FixedSequenceCellCycleModel::SetG1Duration()
{
    CellCycleTimesGenerator* p_cell_cycle_times_generator = CellCycleTimesGenerator::Instance();
 
    if (    mpCell->GetCellProliferativeType()->IsType<StemCellProliferativeType>()
            || mpCell->GetCellProliferativeType()->IsType<TransitCellProliferativeType>() )
    {
        // Generate an exponential random number with mScale
        mG1Duration = p_cell_cycle_times_generator->GetNextCellCycleTime();
    }
    else if (mpCell->GetCellProliferativeType()->IsType<DifferentiatedCellProliferativeType>())
    {
        mG1Duration = DBL_MAX;
    }
    else
    {
        NEVER_REACHED;
    }
}
 
void FixedSequenceCellCycleModel::SetRate(double rate)
{
    CellCycleTimesGenerator* p_cell_cycle_times_generator = CellCycleTimesGenerator::Instance();
    p_cell_cycle_times_generator->SetRate(rate);
    mTransitCellG1Duration = 1.0/rate;
    mStemCellG1Duration = 1.0/rate;
}
 
double FixedSequenceCellCycleModel::GetRate()
{
    CellCycleTimesGenerator* p_cell_cycle_times_generator = CellCycleTimesGenerator::Instance();
    return p_cell_cycle_times_generator->GetRate();
}
 
void FixedSequenceCellCycleModel::SetStemCellG1Duration(double stemCellG1Duration)
{
    EXCEPTION("This cell cycle model does not differentiate stem cells and transit cells, please use SetRate() instead");
}
 
void FixedSequenceCellCycleModel::SetTransitCellG1Duration(double transitCellG1Duration)
{
    EXCEPTION("This cell cycle model does not differentiate stem cells and transit cells, please use SetRate() instead");
}
 
void FixedSequenceCellCycleModel::OutputCellCycleModelParameters(out_stream& rParamsFile)
{
     *rParamsFile << "\t\t\t<Rate>" << CellCycleTimesGenerator::Instance()->GetRate() << "</Rate>\n";
 
    // Call method on direct parent class
    AbstractSimpleGenerationalCellCycleModel::OutputCellCycleModelParameters(rParamsFile);
}
// Serialization for Boost >= 1.36
#include "SerializationExportWrapperForCpp.hpp"
CHASTE_CLASS_EXPORT(FixedSequenceCellCycleModel)