Chaste Release::3.1
SimpleOxygenBasedCellCycleModel Class Reference

#include <SimpleOxygenBasedCellCycleModel.hpp>

Inheritance diagram for SimpleOxygenBasedCellCycleModel:
Collaboration diagram for SimpleOxygenBasedCellCycleModel:

List of all members.

Public Member Functions

 SimpleOxygenBasedCellCycleModel ()
void UpdateCellCyclePhase ()
void UpdateHypoxicDuration ()
double GetCurrentHypoxicDuration ()
double GetCurrentHypoxiaOnsetTime ()
AbstractCellCycleModelCreateCellCycleModel ()
double GetHypoxicConcentration ()
void SetHypoxicConcentration (double hypoxicConcentration)
double GetQuiescentConcentration ()
void SetQuiescentConcentration (double quiescentConcentration)
double GetCriticalHypoxicDuration ()
void SetCriticalHypoxicDuration (double criticalHypoxicDuration)
void SetCurrentHypoxiaOnsetTime (double currentHypoxiaOnsetTime)
virtual void OutputCellCycleModelParameters (out_stream &rParamsFile)

Protected Attributes

double mCurrentHypoxicDuration
double mCurrentHypoxiaOnsetTime
double mHypoxicConcentration
double mQuiescentConcentration
double mCriticalHypoxicDuration

Private Member Functions

template<class Archive >
void serialize (Archive &archive, const unsigned int version)

Friends

class boost::serialization::access

Detailed Description

Simple oxygen-based cell-cycle model.

A simple oxygen-dependent cell-cycle model that inherits from AbstractSimpleCellCycleModel. The duration of G1 phase depends on the local oxygen concentration. A prolonged period of acute hypoxia leads to the cell being labelled as apoptotic. This model allows for quiescence imposed by transient periods of hypoxia, followed by reoxygenation.

Definition at line 51 of file SimpleOxygenBasedCellCycleModel.hpp.


Constructor & Destructor Documentation

SimpleOxygenBasedCellCycleModel::SimpleOxygenBasedCellCycleModel ( )

Member Function Documentation

double SimpleOxygenBasedCellCycleModel::GetCriticalHypoxicDuration ( )
Returns:
mCriticalHypoxicDuration

Definition at line 175 of file SimpleOxygenBasedCellCycleModel.cpp.

References mCriticalHypoxicDuration.

double SimpleOxygenBasedCellCycleModel::GetCurrentHypoxiaOnsetTime ( )
Returns:
mCurrentHypoxiaOnsetTime

Definition at line 56 of file SimpleOxygenBasedCellCycleModel.cpp.

References mCurrentHypoxiaOnsetTime.

double SimpleOxygenBasedCellCycleModel::GetCurrentHypoxicDuration ( )
Returns:
mCurrentHypoxicDuration

Definition at line 51 of file SimpleOxygenBasedCellCycleModel.cpp.

References mCurrentHypoxicDuration.

double SimpleOxygenBasedCellCycleModel::GetHypoxicConcentration ( )
Returns:
mHypoxicConcentration

Definition at line 151 of file SimpleOxygenBasedCellCycleModel.cpp.

References mHypoxicConcentration.

double SimpleOxygenBasedCellCycleModel::GetQuiescentConcentration ( )
Returns:
mQuiescentConcentration

Definition at line 163 of file SimpleOxygenBasedCellCycleModel.cpp.

References mQuiescentConcentration.

void SimpleOxygenBasedCellCycleModel::OutputCellCycleModelParameters ( out_stream &  rParamsFile) [virtual]

Outputs cell cycle model parameters to file.

Parameters:
rParamsFilethe file stream to which the parameters are output

Reimplemented from AbstractSimpleCellCycleModel.

Reimplemented in StochasticOxygenBasedCellCycleModel.

Definition at line 192 of file SimpleOxygenBasedCellCycleModel.cpp.

References mCriticalHypoxicDuration, mHypoxicConcentration, and mQuiescentConcentration.

template<class Archive >
void SimpleOxygenBasedCellCycleModel::serialize ( Archive &  archive,
const unsigned int  version 
) [inline, private]

Archive the cell-cycle model.

Parameters:
archivethe archive
versionthe current version of this class

Reimplemented from AbstractSimpleCellCycleModel.

Reimplemented in StochasticOxygenBasedCellCycleModel.

Definition at line 57 of file SimpleOxygenBasedCellCycleModel.hpp.

References mCriticalHypoxicDuration, mCurrentHypoxiaOnsetTime, mCurrentHypoxicDuration, mHypoxicConcentration, and mQuiescentConcentration.

void SimpleOxygenBasedCellCycleModel::SetCriticalHypoxicDuration ( double  criticalHypoxicDuration)

Set method for mCriticalHypoxicDuration.

Parameters:
criticalHypoxicDurationthe new value of mCriticalHypoxicDuration

Definition at line 180 of file SimpleOxygenBasedCellCycleModel.cpp.

References mCriticalHypoxicDuration.

Referenced by StochasticOxygenBasedCellCycleModel::CreateCellCycleModel(), and CreateCellCycleModel().

void SimpleOxygenBasedCellCycleModel::SetCurrentHypoxiaOnsetTime ( double  currentHypoxiaOnsetTime)

Set method for mCurrentHypoxiaOnsetTime.

Parameters:
currentHypoxiaOnsetTimethe new value of mCurrentHypoxiaOnsetTime

Definition at line 186 of file SimpleOxygenBasedCellCycleModel.cpp.

References mCurrentHypoxiaOnsetTime.

Referenced by StochasticOxygenBasedCellCycleModel::CreateCellCycleModel(), and CreateCellCycleModel().

void SimpleOxygenBasedCellCycleModel::SetHypoxicConcentration ( double  hypoxicConcentration)

Set method for mHypoxicConcentration.

Parameters:
hypoxicConcentrationthe new value of mHypoxicConcentration

Definition at line 156 of file SimpleOxygenBasedCellCycleModel.cpp.

References mHypoxicConcentration.

Referenced by StochasticOxygenBasedCellCycleModel::CreateCellCycleModel(), and CreateCellCycleModel().

void SimpleOxygenBasedCellCycleModel::SetQuiescentConcentration ( double  quiescentConcentration)

Set method for mQuiescentConcentration.

Parameters:
quiescentConcentrationthe new value of mQuiescentConcentration

Definition at line 168 of file SimpleOxygenBasedCellCycleModel.cpp.

References mQuiescentConcentration.

Referenced by StochasticOxygenBasedCellCycleModel::CreateCellCycleModel(), and CreateCellCycleModel().


Friends And Related Function Documentation

friend class boost::serialization::access [friend]

Needed for serialization.

Reimplemented from AbstractSimpleCellCycleModel.

Reimplemented in StochasticOxygenBasedCellCycleModel.

Definition at line 55 of file SimpleOxygenBasedCellCycleModel.hpp.


Member Data Documentation

How long the current period of hypoxia has lasted. Has units of hours.

Definition at line 73 of file SimpleOxygenBasedCellCycleModel.hpp.

Referenced by GetCurrentHypoxicDuration(), serialize(), and UpdateHypoxicDuration().

Non-dimensionalized oxygen concentration below which cells are considered to be hypoxic. A prolonged period of hypoxia causes the cell to become apoptotic.

Definition at line 85 of file SimpleOxygenBasedCellCycleModel.hpp.

Referenced by StochasticOxygenBasedCellCycleModel::CreateCellCycleModel(), CreateCellCycleModel(), GetHypoxicConcentration(), OutputCellCycleModelParameters(), serialize(), SetHypoxicConcentration(), and UpdateHypoxicDuration().

Non-dimensionalized oxygen concentration below which cells are considered to be quiescent and slow their progress through the G1 phase of the cell cycle.

Definition at line 92 of file SimpleOxygenBasedCellCycleModel.hpp.

Referenced by StochasticOxygenBasedCellCycleModel::CreateCellCycleModel(), CreateCellCycleModel(), GetQuiescentConcentration(), OutputCellCycleModelParameters(), serialize(), SetQuiescentConcentration(), and UpdateCellCyclePhase().


The documentation for this class was generated from the following files: