Chaste  Release::2018.1
LuoRudySpiralWaveCellFactory.hpp
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36 #ifndef LUORUDYSPIRALWAVECELLFACTORY_HPP_
37 #define LUORUDYSPIRALWAVECELLFACTORY_HPP_
38 
39 #include "LuoRudy1991BackwardEuler.hpp"
40 #include "AbstractCardiacCellFactory.hpp"
41 #include "MultiStimulus.hpp"
42 #include "SimpleStimulus.hpp"
43 
50 {
51 private:
53  boost::shared_ptr<SimpleStimulus> mpS1Stimulus;
55  boost::shared_ptr<SimpleStimulus> mpS2Stimulus;
57  boost::shared_ptr<MultiStimulus> mpBothStimulus;
59  double mXExtent;
61  double mYExtent;
62 public:
69  LuoRudySpiralWaveCellFactory(double xExtent, double yExtent)
71  mpS1Stimulus(new SimpleStimulus(-50000.0, 2, 0)),
72  mpS2Stimulus(new SimpleStimulus(-70000.0, 2, 45)),
74  mXExtent(xExtent),
75  mYExtent(yExtent)
76  {
77  mpBothStimulus->AddStimulus(mpS1Stimulus);
78  mpBothStimulus->AddStimulus(mpS2Stimulus);
79  }
80 
91  {
92  double x = pNode->rGetLocation()[0];
93  double y = pNode->rGetLocation()[1];
94 
95  double x_threshold_for_S1 = 0.1 + 1e-6;
96  double x_threshold_for_S2 = mXExtent*0.6;
97  double y_threshold_for_S2 = mYExtent*0.5;
98 
99  AbstractCardiacCell* p_cell;
100  if (x < x_threshold_for_S1)
101  {
102  if (y < y_threshold_for_S2)
103  {
104  p_cell = new CellLuoRudy1991FromCellMLBackwardEuler(mpSolver, mpBothStimulus);
105  }
106  else
107  {
108  p_cell = new CellLuoRudy1991FromCellMLBackwardEuler(mpSolver, mpS1Stimulus);
109  }
110  }
111  else if ((x < x_threshold_for_S2) && (y < y_threshold_for_S2))
112  {
113  p_cell = new CellLuoRudy1991FromCellMLBackwardEuler(mpSolver, mpS2Stimulus);
114  }
115  else
116  {
117  p_cell = new CellLuoRudy1991FromCellMLBackwardEuler(mpSolver, this->mpZeroStimulus);
118  }
119 
120  // Alter parameters to match those used in
121  // Qu et al. Origins of Spiral Wave Meander and Breakup... Annals of Biomedical Eng. 28:755-771 (2000).
122  p_cell->SetParameter("membrane_L_type_calcium_current_conductance",0); // slow inward current in original model.
123 
124  unsigned node_index = pNode->GetIndex();
125  if (node_index==0)
126  {
127 // std::cout << "[K_o] = " << p_cell->GetAnyVariable("extracellular_potassium_concentration") << "mM \n";
128 // std::cout << "[K_i] = " << p_cell->GetAnyVariable("cytosolic_potassium_concentration") << "mM \n";
129 // std::cout << "[Na_o] = " << p_cell->GetAnyVariable("extracellular_sodium_concentration") << "mM \n";
130 // std::cout << "[Na_i] = " << p_cell->GetAnyVariable("cytosolic_sodium_concentration") << "mM \n";
131  std::cout << "G_si = " << p_cell->GetAnyVariable("membrane_L_type_calcium_current_conductance") << "\n";
132 // std::cout << "G_Na = " << p_cell->GetAnyVariable("membrane_fast_sodium_current_conductance") << "mM \n";
133 // std::cout << "G_K = " << p_cell->GetAnyVariable("membrane_rapid_delayed_rectifier_potassium_current_conductance") << "mM \n";
134 // std::cout << "G_K1 = " << p_cell->GetAnyVariable("membrane_inward_rectifier_potassium_current_conductance") << "mM \n";
135  }
136  return p_cell;
137  }
138 };
139 
140 #endif // LUORUDYSPIRALWAVECELLFACTORY_HPP_
Definition: Node.hpp:58
boost::shared_ptr< ZeroStimulus > mpZeroStimulus
boost::shared_ptr< AbstractIvpOdeSolver > mpSolver
AbstractCardiacCell * CreateCardiacCellForTissueNode(Node< 2 > *pNode)
double GetAnyVariable(const std::string &rName, double time=0.0)
boost::shared_ptr< MultiStimulus > mpBothStimulus
void SetParameter(const std::string &rParameterName, double value)
const c_vector< double, SPACE_DIM > & rGetLocation() const
Definition: Node.cpp:139
unsigned GetIndex() const
Definition: Node.cpp:158
boost::shared_ptr< SimpleStimulus > mpS2Stimulus
LuoRudySpiralWaveCellFactory(double xExtent, double yExtent)
boost::shared_ptr< SimpleStimulus > mpS1Stimulus