BernoulliTrialCellCycleModel.cpp

/*

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*/

#include "BernoulliTrialCellCycleModel.hpp"
#include "RandomNumberGenerator.hpp"
#include "DifferentiatedCellProliferativeType.hpp"

BernoulliTrialCellCycleModel::BernoulliTrialCellCycleModel()
    : AbstractCellCycleModel(),
      mDivisionProbability(0.1),
      mMinimumDivisionAge(1.0)
{
}

BernoulliTrialCellCycleModel::BernoulliTrialCellCycleModel(const BernoulliTrialCellCycleModel& rModel)
   : AbstractCellCycleModel(rModel),
     mDivisionProbability(rModel.mDivisionProbability),
     mMinimumDivisionAge(rModel.mMinimumDivisionAge)
{
    /*
     * Initialize only those member variables defined in this class.
     *
     * The member variables mBirthTime, mReadyToDivide and mDimension
     * are initialized in the AbstractCellCycleModel constructor.
     */
}

bool BernoulliTrialCellCycleModel::ReadyToDivide()
{
    assert(mpCell != nullptr);

    if (!mReadyToDivide)
    {
        if (GetAge() > mMinimumDivisionAge)
        {
            double dt = SimulationTime::Instance()->GetTimeStep();
            if (!(mpCell->GetCellProliferativeType()->IsType<DifferentiatedCellProliferativeType>()))
            {
                RandomNumberGenerator* p_gen = RandomNumberGenerator::Instance();
                if (p_gen->ranf() < mDivisionProbability*dt)
                {
                    mReadyToDivide = true;
                }
            }
        }
    }
    return mReadyToDivide;
}

AbstractCellCycleModel* BernoulliTrialCellCycleModel::CreateCellCycleModel()
{
    return new BernoulliTrialCellCycleModel(*this);
}

void BernoulliTrialCellCycleModel::SetDivisionProbability(double divisionProbability)
{
    mDivisionProbability = divisionProbability;
}

double BernoulliTrialCellCycleModel::GetDivisionProbability()
{
    return mDivisionProbability;
}

void BernoulliTrialCellCycleModel::SetMinimumDivisionAge(double minimumDivisionAge)
{
    mMinimumDivisionAge = minimumDivisionAge;
}

double BernoulliTrialCellCycleModel::GetMinimumDivisionAge()
{
    return mMinimumDivisionAge;
}

double BernoulliTrialCellCycleModel::GetAverageTransitCellCycleTime()
{
    return 1.0/mDivisionProbability;
}

double BernoulliTrialCellCycleModel::GetAverageStemCellCycleTime()
{
    return 1.0/mDivisionProbability;
}

void BernoulliTrialCellCycleModel::OutputCellCycleModelParameters(out_stream& rParamsFile)
{
    *rParamsFile << "\t\t\t<DivisionProbability>" << mDivisionProbability << "</DivisionProbability>\n";
    *rParamsFile << "\t\t\t<MinimumDivisionAge>" << mMinimumDivisionAge << "</MinimumDivisionAge>\n";

    // Call method on direct parent class
    AbstractCellCycleModel::OutputCellCycleModelParameters(rParamsFile);
}

// Serialization for Boost >= 1.36
#include "SerializationExportWrapperForCpp.hpp"
CHASTE_CLASS_EXPORT(BernoulliTrialCellCycleModel)