TenTusscher2006OdeSystem Class Reference

#include <TenTusscher2006OdeSystem.hpp>

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List of all members.

Public Member Functions

 TenTusscher2006OdeSystem (boost::shared_ptr< AbstractIvpOdeSolver > pSolver, boost::shared_ptr< AbstractStimulusFunction > pIntracellularStimulus)
 ~TenTusscher2006OdeSystem ()
void EvaluateYDerivatives (double time, const std::vector< double > &rY, std::vector< double > &rDY)
void SetScaleFactorGks (double sfgks)
void SetScaleFactorIto (double sfito)
void SetScaleFactorGkr (double sfgkr)
double GetIIonic ()

Private Member Functions

void VerifyStateVariables ()

Private Attributes

double mScaleFactorGks
double mScaleFactorIto
double mScaleFactorGkr

Static Private Attributes

static const double L_type_Ca_current_g_CaL = 0.0000398
static const double calcium_background_current_g_bca = 0.000592
static const double calcium_dynamics_Buf_c = 0.2
static const double calcium_dynamics_Buf_sr = 10.0
static const double calcium_dynamics_Buf_ss = 0.4
static const double calcium_dynamics_Ca_o = 2.0
static const double calcium_dynamics_EC = 1.5
static const double calcium_dynamics_K_buf_c = 0.001
static const double calcium_dynamics_K_buf_sr = 0.3
static const double calcium_dynamics_K_buf_ss = 0.00025
static const double calcium_dynamics_K_up = 0.00025
static const double calcium_dynamics_V_leak = 0.00036
static const double calcium_dynamics_V_rel = 0.102
static const double calcium_dynamics_V_sr = 0.001094
static const double calcium_dynamics_V_ss = 0.00005468
static const double calcium_dynamics_V_xfer = 0.0038
static const double calcium_dynamics_Vmax_up = 0.006375
static const double calcium_dynamics_k1_prime = 0.15
static const double calcium_dynamics_k2_prime = 0.045
static const double calcium_dynamics_k3 = 0.06
static const double calcium_dynamics_k4 = 0.005
static const double calcium_dynamics_max_sr = 2.5
static const double calcium_dynamics_min_sr = 1.0
static const double calcium_pump_current_K_pCa = 0.0005
static const double calcium_pump_current_g_pCa = 0.1238
static const double fast_sodium_current_g_Na = 14.838
static const double inward_rectifier_potassium_current_g_K1 = 5.405
static const double membrane_Cm = 0.185
static const double membrane_F = 96485.3415
static const double membrane_R = 8314.472
static const double membrane_T = 310.0
static const double membrane_V_c = 0.016404
static const double potassium_dynamics_K_o = 5.4
static const double potassium_pump_current_g_pK = 0.0146
static const double rapid_time_dependent_potassium_current_g_Kr = 0.153
static const double reversal_potentials_P_kna = 0.03
static const double slow_time_dependent_potassium_current_g_Ks = 0.392
static const double sodium_background_current_g_bna = 0.00029
static const double sodium_calcium_exchanger_current_K_NaCa = 1000.0
static const double sodium_calcium_exchanger_current_K_sat = 0.1
static const double sodium_calcium_exchanger_current_Km_Ca = 1.38
static const double sodium_calcium_exchanger_current_Km_Nai = 87.5
static const double sodium_calcium_exchanger_current_alpha = 2.5
static const double sodium_calcium_exchanger_current_gamma = 0.35
static const double sodium_dynamics_Na_o = 140.0
static const double sodium_potassium_pump_current_K_mNa = 40.0
static const double sodium_potassium_pump_current_K_mk = 1.0
static const double sodium_potassium_pump_current_P_NaK = 2.724
static const double transient_outward_current_g_to = 0.294

Detailed Description

This class sets up the equations for the TenTusscher 2006 model. This is for an epicardial cell.

Definition at line 39 of file TenTusscher2006OdeSystem.hpp.

Constructor & Destructor Documentation

TenTusscher2006OdeSystem::TenTusscher2006OdeSystem ( boost::shared_ptr< AbstractIvpOdeSolver >  pSolver,
boost::shared_ptr< AbstractStimulusFunction >  pIntracellularStimulus 
)

Constructor

Parameters:
pSolver is a pointer to the ODE solver
pIntracellularStimulus is a pointer to the intracellular stimulus

Definition at line 91 of file TenTusscher2006OdeSystem.cpp.

References AbstractCardiacCell::Init(), OdeSystemInformation< ODE_SYSTEM >::Instance(), AbstractOdeSystem::mpSystemInfo, mScaleFactorGkr, mScaleFactorGks, and mScaleFactorIto.

TenTusscher2006OdeSystem::~TenTusscher2006OdeSystem ( void   ) 

Destructor

Definition at line 107 of file TenTusscher2006OdeSystem.cpp.

Member Function Documentation

void TenTusscher2006OdeSystem::VerifyStateVariables (  )  [private, virtual]

This private method will check that gates are within 0 and 1 and concentrations are positive

Reimplemented from AbstractCardiacCell.

Definition at line 371 of file TenTusscher2006OdeSystem.cpp.

References AbstractOdeSystem::DumpState(), and AbstractOdeSystem::rGetStateVariables().

Referenced by EvaluateYDerivatives().

void TenTusscher2006OdeSystem::EvaluateYDerivatives ( double  time,
const std::vector< double > &  rY,
std::vector< double > &  rDY 
) [virtual]

Fill in a vector representing the RHS of the TenTusscher2006 system of Odes at each time step, y' = [y1' ... yn']. Some ODE solver will call this function repeatedly to solve for y = [y1 ... yn].

Parameters:
time the current time, in milliseconds
rY current values of the state variables
rDY to be filled in with derivatives

Implements AbstractOdeSystem.

Definition at line 124 of file TenTusscher2006OdeSystem.cpp.

References calcium_background_current_g_bca, calcium_dynamics_Buf_c, calcium_dynamics_Buf_sr, calcium_dynamics_Buf_ss, calcium_dynamics_Ca_o, calcium_dynamics_EC, calcium_dynamics_k1_prime, calcium_dynamics_k2_prime, calcium_dynamics_k3, calcium_dynamics_k4, calcium_dynamics_K_buf_c, calcium_dynamics_K_buf_sr, calcium_dynamics_K_buf_ss, calcium_dynamics_K_up, calcium_dynamics_max_sr, calcium_dynamics_min_sr, calcium_dynamics_V_leak, calcium_dynamics_V_rel, calcium_dynamics_V_sr, calcium_dynamics_V_ss, calcium_dynamics_V_xfer, calcium_dynamics_Vmax_up, calcium_pump_current_g_pCa, calcium_pump_current_K_pCa, fast_sodium_current_g_Na, AbstractCardiacCell::GetStimulus(), inward_rectifier_potassium_current_g_K1, L_type_Ca_current_g_CaL, membrane_Cm, membrane_F, membrane_R, membrane_T, membrane_V_c, mScaleFactorGkr, mScaleFactorGks, mScaleFactorIto, AbstractCardiacCell::mSetVoltageDerivativeToZero, potassium_dynamics_K_o, potassium_pump_current_g_pK, rapid_time_dependent_potassium_current_g_Kr, reversal_potentials_P_kna, slow_time_dependent_potassium_current_g_Ks, sodium_background_current_g_bna, sodium_calcium_exchanger_current_alpha, sodium_calcium_exchanger_current_gamma, sodium_calcium_exchanger_current_K_NaCa, sodium_calcium_exchanger_current_K_sat, sodium_calcium_exchanger_current_Km_Ca, sodium_calcium_exchanger_current_Km_Nai, sodium_dynamics_Na_o, sodium_potassium_pump_current_K_mk, sodium_potassium_pump_current_K_mNa, sodium_potassium_pump_current_P_NaK, transient_outward_current_g_to, and VerifyStateVariables().

void TenTusscher2006OdeSystem::SetScaleFactorGks ( double  sfgks  ) 

Set the scale factor for Gks in order to differentiate epi M and endo cells

Parameters:
sfgks is the scale factor for Gks conductance

Definition at line 111 of file TenTusscher2006OdeSystem.cpp.

References mScaleFactorGks.

void TenTusscher2006OdeSystem::SetScaleFactorIto ( double  sfito  ) 

Set the scale factor for Gks in order to differentiate epi M and endo cells

Parameters:
sfito is the scale factor for Ito current

Definition at line 115 of file TenTusscher2006OdeSystem.cpp.

References mScaleFactorIto.

void TenTusscher2006OdeSystem::SetScaleFactorGkr ( double  sfgkr  ) 

Set the scale factor for Gks in order to differentiate epi M and endo cells

Parameters:
sfgkr is the scale factor for Gkr conductance

Definition at line 119 of file TenTusscher2006OdeSystem.cpp.

References mScaleFactorGkr.

double TenTusscher2006OdeSystem::GetIIonic (  )  [virtual]

Returns the ionic current

Returns:
the total ionic current

Implements AbstractCardiacCell.

Definition at line 301 of file TenTusscher2006OdeSystem.cpp.

References calcium_background_current_g_bca, calcium_dynamics_Ca_o, calcium_pump_current_g_pCa, calcium_pump_current_K_pCa, fast_sodium_current_g_Na, inward_rectifier_potassium_current_g_K1, L_type_Ca_current_g_CaL, membrane_F, membrane_R, membrane_T, mScaleFactorGkr, mScaleFactorGks, mScaleFactorIto, AbstractOdeSystem::mStateVariables, potassium_dynamics_K_o, potassium_pump_current_g_pK, rapid_time_dependent_potassium_current_g_Kr, reversal_potentials_P_kna, slow_time_dependent_potassium_current_g_Ks, sodium_background_current_g_bna, sodium_calcium_exchanger_current_alpha, sodium_calcium_exchanger_current_gamma, sodium_calcium_exchanger_current_K_NaCa, sodium_calcium_exchanger_current_K_sat, sodium_calcium_exchanger_current_Km_Ca, sodium_calcium_exchanger_current_Km_Nai, sodium_dynamics_Na_o, sodium_potassium_pump_current_K_mk, sodium_potassium_pump_current_K_mNa, sodium_potassium_pump_current_P_NaK, and transient_outward_current_g_to.

Member Data Documentation

double TenTusscher2006OdeSystem::mScaleFactorGks [private]

Scale factor for Gks

Definition at line 44 of file TenTusscher2006OdeSystem.hpp.

Referenced by EvaluateYDerivatives(), GetIIonic(), SetScaleFactorGks(), and TenTusscher2006OdeSystem().

double TenTusscher2006OdeSystem::mScaleFactorIto [private]

Scale factor for Gto

Definition at line 45 of file TenTusscher2006OdeSystem.hpp.

Referenced by EvaluateYDerivatives(), GetIIonic(), SetScaleFactorIto(), and TenTusscher2006OdeSystem().

double TenTusscher2006OdeSystem::mScaleFactorGkr [private]

Scale factor for Gkr

Definition at line 46 of file TenTusscher2006OdeSystem.hpp.

Referenced by EvaluateYDerivatives(), GetIIonic(), SetScaleFactorGkr(), and TenTusscher2006OdeSystem().

const double TenTusscher2006OdeSystem::L_type_Ca_current_g_CaL = 0.0000398 [static, private]

nanoS_per_picoF

Definition at line 51 of file TenTusscher2006OdeSystem.hpp.

Referenced by EvaluateYDerivatives(), and GetIIonic().

const double TenTusscher2006OdeSystem::calcium_background_current_g_bca = 0.000592 [static, private]

nanoS_per_picoF

Definition at line 52 of file TenTusscher2006OdeSystem.hpp.

Referenced by EvaluateYDerivatives(), and GetIIonic().

const double TenTusscher2006OdeSystem::calcium_dynamics_Buf_c = 0.2 [static, private]

millimolar

Definition at line 53 of file TenTusscher2006OdeSystem.hpp.

Referenced by EvaluateYDerivatives().

const double TenTusscher2006OdeSystem::calcium_dynamics_Buf_sr = 10.0 [static, private]

millimolar

Definition at line 54 of file TenTusscher2006OdeSystem.hpp.

Referenced by EvaluateYDerivatives().

const double TenTusscher2006OdeSystem::calcium_dynamics_Buf_ss = 0.4 [static, private]

millimolar

Definition at line 55 of file TenTusscher2006OdeSystem.hpp.

Referenced by EvaluateYDerivatives().

const double TenTusscher2006OdeSystem::calcium_dynamics_Ca_o = 2.0 [static, private]

millimolar

Definition at line 56 of file TenTusscher2006OdeSystem.hpp.

Referenced by EvaluateYDerivatives(), and GetIIonic().

const double TenTusscher2006OdeSystem::calcium_dynamics_EC = 1.5 [static, private]

millimolar

Definition at line 57 of file TenTusscher2006OdeSystem.hpp.

Referenced by EvaluateYDerivatives().

const double TenTusscher2006OdeSystem::calcium_dynamics_K_buf_c = 0.001 [static, private]

millimolar

Definition at line 58 of file TenTusscher2006OdeSystem.hpp.

Referenced by EvaluateYDerivatives().

const double TenTusscher2006OdeSystem::calcium_dynamics_K_buf_sr = 0.3 [static, private]

millimolar

Definition at line 59 of file TenTusscher2006OdeSystem.hpp.

Referenced by EvaluateYDerivatives().

const double TenTusscher2006OdeSystem::calcium_dynamics_K_buf_ss = 0.00025 [static, private]

millimolar

Definition at line 60 of file TenTusscher2006OdeSystem.hpp.

Referenced by EvaluateYDerivatives().

const double TenTusscher2006OdeSystem::calcium_dynamics_K_up = 0.00025 [static, private]

millimolar

Definition at line 61 of file TenTusscher2006OdeSystem.hpp.

Referenced by EvaluateYDerivatives().

const double TenTusscher2006OdeSystem::calcium_dynamics_V_leak = 0.00036 [static, private]

millimolar_per_millisecond

Definition at line 62 of file TenTusscher2006OdeSystem.hpp.

Referenced by EvaluateYDerivatives().

const double TenTusscher2006OdeSystem::calcium_dynamics_V_rel = 0.102 [static, private]

millimolar_per_millisecond

Definition at line 63 of file TenTusscher2006OdeSystem.hpp.

Referenced by EvaluateYDerivatives().

const double TenTusscher2006OdeSystem::calcium_dynamics_V_sr = 0.001094 [static, private]

micrometre3

Definition at line 64 of file TenTusscher2006OdeSystem.hpp.

Referenced by EvaluateYDerivatives().

const double TenTusscher2006OdeSystem::calcium_dynamics_V_ss = 0.00005468 [static, private]

micrometre3

Definition at line 65 of file TenTusscher2006OdeSystem.hpp.

Referenced by EvaluateYDerivatives().

const double TenTusscher2006OdeSystem::calcium_dynamics_V_xfer = 0.0038 [static, private]

millimolar_per_millisecond

Definition at line 66 of file TenTusscher2006OdeSystem.hpp.

Referenced by EvaluateYDerivatives().

const double TenTusscher2006OdeSystem::calcium_dynamics_Vmax_up = 0.006375 [static, private]

millimolar_per_millisecond

Definition at line 67 of file TenTusscher2006OdeSystem.hpp.

Referenced by EvaluateYDerivatives().

const double TenTusscher2006OdeSystem::calcium_dynamics_k1_prime = 0.15 [static, private]

per_millimolar2_per_millisecond

Definition at line 68 of file TenTusscher2006OdeSystem.hpp.

Referenced by EvaluateYDerivatives().

const double TenTusscher2006OdeSystem::calcium_dynamics_k2_prime = 0.045 [static, private]

per_millimolar_per_millisecond

Definition at line 69 of file TenTusscher2006OdeSystem.hpp.

Referenced by EvaluateYDerivatives().

const double TenTusscher2006OdeSystem::calcium_dynamics_k3 = 0.06 [static, private]

per_millisecond

Definition at line 70 of file TenTusscher2006OdeSystem.hpp.

Referenced by EvaluateYDerivatives().

const double TenTusscher2006OdeSystem::calcium_dynamics_k4 = 0.005 [static, private]

per_millisecond

Definition at line 71 of file TenTusscher2006OdeSystem.hpp.

Referenced by EvaluateYDerivatives().

const double TenTusscher2006OdeSystem::calcium_dynamics_max_sr = 2.5 [static, private]

dimensionless

Definition at line 72 of file TenTusscher2006OdeSystem.hpp.

Referenced by EvaluateYDerivatives().

const double TenTusscher2006OdeSystem::calcium_dynamics_min_sr = 1.0 [static, private]

dimensionless

Definition at line 73 of file TenTusscher2006OdeSystem.hpp.

Referenced by EvaluateYDerivatives().

const double TenTusscher2006OdeSystem::calcium_pump_current_K_pCa = 0.0005 [static, private]

millimolar

Definition at line 74 of file TenTusscher2006OdeSystem.hpp.

Referenced by EvaluateYDerivatives(), and GetIIonic().

const double TenTusscher2006OdeSystem::calcium_pump_current_g_pCa = 0.1238 [static, private]

nanoS_per_picoF

Definition at line 75 of file TenTusscher2006OdeSystem.hpp.

Referenced by EvaluateYDerivatives(), and GetIIonic().

const double TenTusscher2006OdeSystem::fast_sodium_current_g_Na = 14.838 [static, private]

nanoS_per_picoF

Definition at line 76 of file TenTusscher2006OdeSystem.hpp.

Referenced by EvaluateYDerivatives(), and GetIIonic().

const double TenTusscher2006OdeSystem::inward_rectifier_potassium_current_g_K1 = 5.405 [static, private]

nanoS_per_picoF

Definition at line 77 of file TenTusscher2006OdeSystem.hpp.

Referenced by EvaluateYDerivatives(), and GetIIonic().

const double TenTusscher2006OdeSystem::membrane_Cm = 0.185 [static, private]

microF_per_cm2

Definition at line 78 of file TenTusscher2006OdeSystem.hpp.

Referenced by EvaluateYDerivatives().

const double TenTusscher2006OdeSystem::membrane_F = 96485.3415 [static, private]

coulomb_per_millimole

Definition at line 79 of file TenTusscher2006OdeSystem.hpp.

Referenced by EvaluateYDerivatives(), and GetIIonic().

const double TenTusscher2006OdeSystem::membrane_R = 8314.472 [static, private]

joule_per_mole_kelvin

Definition at line 80 of file TenTusscher2006OdeSystem.hpp.

Referenced by EvaluateYDerivatives(), and GetIIonic().

const double TenTusscher2006OdeSystem::membrane_T = 310.0 [static, private]

kelvin

Definition at line 81 of file TenTusscher2006OdeSystem.hpp.

Referenced by EvaluateYDerivatives(), and GetIIonic().

const double TenTusscher2006OdeSystem::membrane_V_c = 0.016404 [static, private]

micrometre3

Definition at line 82 of file TenTusscher2006OdeSystem.hpp.

Referenced by EvaluateYDerivatives().

const double TenTusscher2006OdeSystem::potassium_dynamics_K_o = 5.4 [static, private]

millimolar

Definition at line 83 of file TenTusscher2006OdeSystem.hpp.

Referenced by EvaluateYDerivatives(), and GetIIonic().

const double TenTusscher2006OdeSystem::potassium_pump_current_g_pK = 0.0146 [static, private]

nanoS_per_picoF

Definition at line 84 of file TenTusscher2006OdeSystem.hpp.

Referenced by EvaluateYDerivatives(), and GetIIonic().

const double TenTusscher2006OdeSystem::rapid_time_dependent_potassium_current_g_Kr = 0.153 [static, private]

nanoS_per_picoF

Definition at line 85 of file TenTusscher2006OdeSystem.hpp.

Referenced by EvaluateYDerivatives(), and GetIIonic().

const double TenTusscher2006OdeSystem::reversal_potentials_P_kna = 0.03 [static, private]

nanoA_per_millimolar

Definition at line 86 of file TenTusscher2006OdeSystem.hpp.

Referenced by EvaluateYDerivatives(), and GetIIonic().

const double TenTusscher2006OdeSystem::slow_time_dependent_potassium_current_g_Ks = 0.392 [static, private]

nanoS_per_picoF

Definition at line 87 of file TenTusscher2006OdeSystem.hpp.

Referenced by EvaluateYDerivatives(), and GetIIonic().

const double TenTusscher2006OdeSystem::sodium_background_current_g_bna = 0.00029 [static, private]

nanoS_per_picoF

Definition at line 88 of file TenTusscher2006OdeSystem.hpp.

Referenced by EvaluateYDerivatives(), and GetIIonic().

const double TenTusscher2006OdeSystem::sodium_calcium_exchanger_current_K_NaCa = 1000.0 [static, private]

picoA_per_picoF

Definition at line 89 of file TenTusscher2006OdeSystem.hpp.

Referenced by EvaluateYDerivatives(), and GetIIonic().

const double TenTusscher2006OdeSystem::sodium_calcium_exchanger_current_K_sat = 0.1 [static, private]

dimensionless

Definition at line 90 of file TenTusscher2006OdeSystem.hpp.

Referenced by EvaluateYDerivatives(), and GetIIonic().

const double TenTusscher2006OdeSystem::sodium_calcium_exchanger_current_Km_Ca = 1.38 [static, private]

millimolar

Definition at line 91 of file TenTusscher2006OdeSystem.hpp.

Referenced by EvaluateYDerivatives(), and GetIIonic().

const double TenTusscher2006OdeSystem::sodium_calcium_exchanger_current_Km_Nai = 87.5 [static, private]

millimolar

Definition at line 92 of file TenTusscher2006OdeSystem.hpp.

Referenced by EvaluateYDerivatives(), and GetIIonic().

const double TenTusscher2006OdeSystem::sodium_calcium_exchanger_current_alpha = 2.5 [static, private]

dimensionless

Definition at line 93 of file TenTusscher2006OdeSystem.hpp.

Referenced by EvaluateYDerivatives(), and GetIIonic().

const double TenTusscher2006OdeSystem::sodium_calcium_exchanger_current_gamma = 0.35 [static, private]

dimensionless

Definition at line 94 of file TenTusscher2006OdeSystem.hpp.

Referenced by EvaluateYDerivatives(), and GetIIonic().

const double TenTusscher2006OdeSystem::sodium_dynamics_Na_o = 140.0 [static, private]

millimolar

Definition at line 95 of file TenTusscher2006OdeSystem.hpp.

Referenced by EvaluateYDerivatives(), and GetIIonic().

const double TenTusscher2006OdeSystem::sodium_potassium_pump_current_K_mNa = 40.0 [static, private]

millimolar

Definition at line 96 of file TenTusscher2006OdeSystem.hpp.

Referenced by EvaluateYDerivatives(), and GetIIonic().

const double TenTusscher2006OdeSystem::sodium_potassium_pump_current_K_mk = 1.0 [static, private]

millimolar

Definition at line 97 of file TenTusscher2006OdeSystem.hpp.

Referenced by EvaluateYDerivatives(), and GetIIonic().

const double TenTusscher2006OdeSystem::sodium_potassium_pump_current_P_NaK = 2.724 [static, private]

picoA_per_picoF

Definition at line 98 of file TenTusscher2006OdeSystem.hpp.

Referenced by EvaluateYDerivatives(), and GetIIonic().

const double TenTusscher2006OdeSystem::transient_outward_current_g_to = 0.294 [static, private]

nanoS_per_picoF

Definition at line 99 of file TenTusscher2006OdeSystem.hpp.

Referenced by EvaluateYDerivatives(), and GetIIonic().

The documentation for this class was generated from the following files:
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