SimpleWntCellCycleModel.hpp

/*

Copyright (c) 2005-2012, University of Oxford.
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 * Redistributions in binary form must reproduce the above copyright notice,
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   software without specific prior written permission.

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*/

#ifndef SIMPLEWNTCELLCYCLEMODEL_HPP_
#define SIMPLEWNTCELLCYCLEMODEL_HPP_

#include "AbstractSimpleCellCycleModel.hpp"
#include "RandomNumberGenerator.hpp"
#include "WntConcentration.hpp"

// Needed here to avoid serialization errors
#include "WildTypeCellMutationState.hpp"
#include "CellLabel.hpp"
#include "ApcOneHitCellMutationState.hpp"
#include "ApcTwoHitCellMutationState.hpp"
#include "BetaCateninOneHitCellMutationState.hpp"


class SimpleWntCellCycleModel : public AbstractSimpleCellCycleModel
{
private:

    friend class boost::serialization::access;
    template<class Archive>
    void serialize(Archive & archive, const unsigned int version)
    {
        archive & boost::serialization::base_object<AbstractSimpleCellCycleModel>(*this);

        RandomNumberGenerator* p_gen = RandomNumberGenerator::Instance();
        archive & *p_gen;

        archive & mUseCellProliferativeTypeDependentG1Duration;
        archive & mWntStemThreshold;
        archive & mWntTransitThreshold;
        archive & mWntLabelledThreshold;
    }

protected:

    bool mUseCellProliferativeTypeDependentG1Duration;

    double mWntStemThreshold;

    double mWntTransitThreshold;

    double mWntLabelledThreshold;

    double GetWntLevel();

    WntConcentrationType GetWntType();

    void SetG1Duration();

public:

    SimpleWntCellCycleModel();

    virtual void UpdateCellCyclePhase();

    virtual void InitialiseDaughterCell();

    virtual AbstractCellCycleModel* CreateCellCycleModel();

    void SetUseCellProliferativeTypeDependentG1Duration(bool useCellProliferativeTypeDependentG1Duration=true);

    virtual bool CanCellTerminallyDifferentiate();

    double GetWntStemThreshold();

    void SetWntStemThreshold(double wntStemThreshold);

    double GetWntTransitThreshold();

    void SetWntTransitThreshold(double wntTransitThreshold);

    double GetWntLabelledThreshold();

    void SetWntLabelledThreshold(double wntLabelledThreshold);

    virtual void OutputCellCycleModelParameters(out_stream& rParamsFile);
};

#include "SerializationExportWrapper.hpp"
// Declare identifier for the serializer
CHASTE_CLASS_EXPORT(SimpleWntCellCycleModel)

#endif /*SIMPLEWNTCELLCYCLEMODEL_HPP_*/