SimpleWntCellCycleModel.hpp

00001 /*
00002 
00003 Copyright (C) University of Oxford, 2005-2011
00004 
00005 University of Oxford means the Chancellor, Masters and Scholars of the
00006 University of Oxford, having an administrative office at Wellington
00007 Square, Oxford OX1 2JD, UK.
00008 
00009 This file is part of Chaste.
00010 
00011 Chaste is free software: you can redistribute it and/or modify it
00012 under the terms of the GNU Lesser General Public License as published
00013 by the Free Software Foundation, either version 2.1 of the License, or
00014 (at your option) any later version.
00015 
00016 Chaste is distributed in the hope that it will be useful, but WITHOUT
00017 ANY WARRANTY; without even the implied warranty of MERCHANTABILITY or
00018 FITNESS FOR A PARTICULAR PURPOSE.  See the GNU Lesser General Public
00019 License for more details. The offer of Chaste under the terms of the
00020 License is subject to the License being interpreted in accordance with
00021 English Law and subject to any action against the University of Oxford
00022 being under the jurisdiction of the English Courts.
00023 
00024 You should have received a copy of the GNU Lesser General Public License
00025 along with Chaste. If not, see <http://www.gnu.org/licenses/>.
00026 
00027 */
00028 #ifndef SIMPLEWNTCELLCYCLEMODEL_HPP_
00029 #define SIMPLEWNTCELLCYCLEMODEL_HPP_
00030 
00031 #include "AbstractSimpleCellCycleModel.hpp"
00032 #include "RandomNumberGenerator.hpp"
00033 #include "WntConcentration.hpp"
00034 
00035 // Needed here to avoid serialization errors
00036 #include "WildTypeCellMutationState.hpp"
00037 #include "CellLabel.hpp"
00038 #include "ApcOneHitCellMutationState.hpp"
00039 #include "ApcTwoHitCellMutationState.hpp"
00040 #include "BetaCateninOneHitCellMutationState.hpp"
00041 
00042 
00046 class SimpleWntCellCycleModel : public AbstractSimpleCellCycleModel
00047 {
00048 private:
00049 
00051     friend class boost::serialization::access;
00058     template<class Archive>
00059     void serialize(Archive & archive, const unsigned int version)
00060     {
00061         archive & boost::serialization::base_object<AbstractSimpleCellCycleModel>(*this);
00062 
00063         RandomNumberGenerator* p_gen = RandomNumberGenerator::Instance();
00064         archive & *p_gen;
00065 
00066         archive & mUseCellProliferativeTypeDependentG1Duration;
00067         archive & mWntStemThreshold;
00068         archive & mWntTransitThreshold;
00069         archive & mWntLabelledThreshold;
00070     }
00071 
00072 protected:
00073 
00078     bool mUseCellProliferativeTypeDependentG1Duration;
00079 
00083     double mWntStemThreshold;
00084 
00088     double mWntTransitThreshold;
00089 
00093     double mWntLabelledThreshold;
00094 
00098     double GetWntLevel();
00099 
00104     WntConcentrationType GetWntType();
00105 
00115     void SetG1Duration();
00116 
00117 public:
00118 
00123     SimpleWntCellCycleModel();
00124 
00128     virtual void UpdateCellCyclePhase();
00129 
00133     virtual void InitialiseDaughterCell();
00134 
00139     virtual AbstractCellCycleModel* CreateCellCycleModel();
00140 
00145     void SetUseCellProliferativeTypeDependentG1Duration(bool useCellProliferativeTypeDependentG1Duration=true);
00146 
00150     virtual bool CanCellTerminallyDifferentiate();
00151 
00155     double GetWntStemThreshold();
00156 
00162     void SetWntStemThreshold(double wntStemThreshold);
00163 
00167     double GetWntTransitThreshold();
00168 
00174     void SetWntTransitThreshold(double wntTransitThreshold);
00175 
00179     double GetWntLabelledThreshold();
00180 
00186     void SetWntLabelledThreshold(double wntLabelledThreshold);
00187 
00193     virtual void OutputCellCycleModelParameters(out_stream& rParamsFile);
00194 };
00195 
00196 #include "SerializationExportWrapper.hpp"
00197 // Declare identifier for the serializer
00198 CHASTE_CLASS_EXPORT(SimpleWntCellCycleModel)
00199 
00200 #endif /*SIMPLEWNTCELLCYCLEMODEL_HPP_*/

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