RandomCellKiller.hpp

00001 /*
00002 
00003 Copyright (C) University of Oxford, 2005-2011
00004 
00005 University of Oxford means the Chancellor, Masters and Scholars of the
00006 University of Oxford, having an administrative office at Wellington
00007 Square, Oxford OX1 2JD, UK.
00008 
00009 This file is part of Chaste.
00010 
00011 Chaste is free software: you can redistribute it and/or modify it
00012 under the terms of the GNU Lesser General Public License as published
00013 by the Free Software Foundation, either version 2.1 of the License, or
00014 (at your option) any later version.
00015 
00016 Chaste is distributed in the hope that it will be useful, but WITHOUT
00017 ANY WARRANTY; without even the implied warranty of MERCHANTABILITY or
00018 FITNESS FOR A PARTICULAR PURPOSE.  See the GNU Lesser General Public
00019 License for more details. The offer of Chaste under the terms of the
00020 License is subject to the License being interpreted in accordance with
00021 English Law and subject to any action against the University of Oxford
00022 being under the jurisdiction of the English Courts.
00023 
00024 You should have received a copy of the GNU Lesser General Public License
00025 along with Chaste. If not, see <http://www.gnu.org/licenses/>.
00026 
00027 */
00028 #ifndef RANDOMCELLKILLER_HPP_
00029 #define RANDOMCELLKILLER_HPP_
00030 
00031 #include "AbstractCellKiller.hpp"
00032 #include "RandomNumberGenerator.hpp"
00033 
00034 #include "ChasteSerialization.hpp"
00035 #include <boost/serialization/base_object.hpp>
00036 
00037 
00050 template<unsigned DIM>
00051 class RandomCellKiller : public AbstractCellKiller<DIM>
00052 {
00053 private:
00054 
00059      double mProbabilityOfDeathInAnHour;
00060 
00062     friend class boost::serialization::access;
00074     template<class Archive>
00075     void serialize(Archive & archive, const unsigned int version)
00076     {
00077         archive & boost::serialization::base_object<AbstractCellKiller<DIM> >(*this);
00078 
00079         // Make sure the random number generator is archived
00080         RandomNumberGenerator* p_random_generator = RandomNumberGenerator::Instance();
00081         archive & *p_random_generator;
00082         archive & p_random_generator;
00083     }
00084 
00085 public:
00086 
00093     RandomCellKiller(AbstractCellPopulation<DIM>* pCellPopulation, double probabilityOfDeathInAnHour);
00094 
00098     double GetDeathProbabilityInAnHour() const;
00099 
00105     void TestAndLabelSingleCellForApoptosis(CellPtr pCell);
00106 
00111     void TestAndLabelCellsForApoptosisOrDeath();
00112 
00118     void OutputCellKillerParameters(out_stream& rParamsFile);
00119 };
00120 
00121 #include "SerializationExportWrapper.hpp"
00122 EXPORT_TEMPLATE_CLASS_SAME_DIMS(RandomCellKiller)
00123 
00124 namespace boost
00125 {
00126 namespace serialization
00127 {
00131 template<class Archive, unsigned DIM>
00132 inline void save_construct_data(
00133     Archive & ar, const RandomCellKiller<DIM> * t, const BOOST_PFTO unsigned int file_version)
00134 {
00135     // Save data required to construct instance
00136     const AbstractCellPopulation<DIM>* const p_cell_population = t->GetCellPopulation();
00137     ar << p_cell_population;
00138     double prob = t->GetDeathProbabilityInAnHour();
00139     ar << prob;
00140 }
00141 
00145 template<class Archive, unsigned DIM>
00146 inline void load_construct_data(
00147     Archive & ar, RandomCellKiller<DIM> * t, const unsigned int file_version)
00148 {
00149     // Retrieve data from archive required to construct new instance
00150     AbstractCellPopulation<DIM>* p_cell_population;
00151     ar >> p_cell_population;
00152     double prob;
00153     ar >> prob;
00154 
00155     // Invoke inplace constructor to initialise instance
00156     ::new(t)RandomCellKiller<DIM>(p_cell_population, prob);
00157 }
00158 }
00159 } // namespace ...
00160 
00161 #endif /*RANDOMCELLKILLER_HPP_*/

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