AbstractWntOdeBasedCellCycleModel.hpp

00001 /*
00002 
00003 Copyright (C) University of Oxford, 2005-2011
00004 
00005 University of Oxford means the Chancellor, Masters and Scholars of the
00006 University of Oxford, having an administrative office at Wellington
00007 Square, Oxford OX1 2JD, UK.
00008 
00009 This file is part of Chaste.
00010 
00011 Chaste is free software: you can redistribute it and/or modify it
00012 under the terms of the GNU Lesser General Public License as published
00013 by the Free Software Foundation, either version 2.1 of the License, or
00014 (at your option) any later version.
00015 
00016 Chaste is distributed in the hope that it will be useful, but WITHOUT
00017 ANY WARRANTY; without even the implied warranty of MERCHANTABILITY or
00018 FITNESS FOR A PARTICULAR PURPOSE.  See the GNU Lesser General Public
00019 License for more details. The offer of Chaste under the terms of the
00020 License is subject to the License being interpreted in accordance with
00021 English Law and subject to any action against the University of Oxford
00022 being under the jurisdiction of the English Courts.
00023 
00024 You should have received a copy of the GNU Lesser General Public License
00025 along with Chaste. If not, see <http://www.gnu.org/licenses/>.
00026 
00027 */
00028 #ifndef ABSTRACTWNTODEBASEDCELLCYCLEMODEL_HPP_
00029 #define ABSTRACTWNTODEBASEDCELLCYCLEMODEL_HPP_
00030 
00031 #include "ChasteSerialization.hpp"
00032 #include "ClassIsAbstract.hpp"
00033 #include <boost/serialization/base_object.hpp>
00034 
00035 #include "AbstractOdeBasedCellCycleModel.hpp"
00036 #include "WntConcentration.hpp"
00037 
00050 class AbstractWntOdeBasedCellCycleModel : public AbstractOdeBasedCellCycleModel
00051 {
00052 private:
00053 
00055     friend class boost::serialization::access;
00062     template<class Archive>
00063     void serialize(Archive & archive, const unsigned int version)
00064     {
00065         archive & boost::serialization::base_object<AbstractOdeBasedCellCycleModel>(*this);
00066     }
00067 
00068 protected:
00069 
00073     double GetWntLevel();
00074     
00078     void UpdateCellCyclePhase();
00079 
00080 public:
00081 
00087     AbstractWntOdeBasedCellCycleModel(boost::shared_ptr<AbstractCellCycleModelOdeSolver> pOdeSolver = boost::shared_ptr<AbstractCellCycleModelOdeSolver>());
00088 
00092     ~AbstractWntOdeBasedCellCycleModel();
00093 
00101     void ResetForDivision();
00102 
00109     void UpdateCellProliferativeType();
00110 
00115     virtual void ChangeCellProliferativeTypeDueToCurrentBetaCateninLevel()=0;
00116 
00120     double GetAverageTransitCellCycleTime();
00121 
00125     double GetAverageStemCellCycleTime();
00126 
00130     virtual bool CanCellTerminallyDifferentiate();
00131 
00137     virtual void OutputCellCycleModelParameters(out_stream& rParamsFile);
00138 };
00139 
00140 CLASS_IS_ABSTRACT(AbstractWntOdeBasedCellCycleModel)
00141 
00142 #endif /*ABSTRACTWNTODEBASEDCELLCYCLEMODEL_HPP_*/

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