AbstractSimpleCellCycleModel.cpp

00001 /*
00002 
00003 Copyright (C) University of Oxford, 2005-2010
00004 
00005 University of Oxford means the Chancellor, Masters and Scholars of the
00006 University of Oxford, having an administrative office at Wellington
00007 Square, Oxford OX1 2JD, UK.
00008 
00009 This file is part of Chaste.
00010 
00011 Chaste is free software: you can redistribute it and/or modify it
00012 under the terms of the GNU Lesser General Public License as published
00013 by the Free Software Foundation, either version 2.1 of the License, or
00014 (at your option) any later version.
00015 
00016 Chaste is distributed in the hope that it will be useful, but WITHOUT
00017 ANY WARRANTY; without even the implied warranty of MERCHANTABILITY or
00018 FITNESS FOR A PARTICULAR PURPOSE.  See the GNU Lesser General Public
00019 License for more details. The offer of Chaste under the terms of the
00020 License is subject to the License being interpreted in accordance with
00021 English Law and subject to any action against the University of Oxford
00022 being under the jurisdiction of the English Courts.
00023 
00024 You should have received a copy of the GNU Lesser General Public License
00025 along with Chaste. If not, see <http://www.gnu.org/licenses/>.
00026 
00027 */
00028 #include "AbstractSimpleCellCycleModel.hpp"
00029 #include "PetscTools.hpp"
00030 
00031 AbstractSimpleCellCycleModel::AbstractSimpleCellCycleModel()
00032 {
00033 }
00034 
00035 AbstractSimpleCellCycleModel::~AbstractSimpleCellCycleModel()
00036 {
00037 }
00038 
00039 void AbstractSimpleCellCycleModel::Initialise()
00040 {
00041     SetG1Duration();
00042 }
00043 
00044 void AbstractSimpleCellCycleModel::InitialiseDaughterCell()
00045 {
00046     AbstractCellCycleModel::InitialiseDaughterCell();
00047     SetG1Duration();
00048 }
00049 
00050 void AbstractSimpleCellCycleModel::SetG1Duration()
00051 {
00052     assert(mpCell != NULL);
00053 
00054     switch (mCellProliferativeType)
00055     {
00056         case STEM:
00057             mG1Duration = GetStemCellG1Duration();
00058             break;
00059         case TRANSIT:
00060             mG1Duration = GetTransitCellG1Duration();
00061             break;
00062         case DIFFERENTIATED:
00063             mG1Duration = DBL_MAX;
00064             break;
00065         default:
00066             NEVER_REACHED;
00067     }
00068 }
00069 
00070 void AbstractSimpleCellCycleModel::ResetForDivision()
00071 {
00072     AbstractCellCycleModel::ResetForDivision();
00073     mBirthTime = SimulationTime::Instance()->GetTime();
00074     SetG1Duration();
00075 }
00076 
00077 void AbstractSimpleCellCycleModel::UpdateCellCyclePhase()
00078 {
00079     double time_since_birth = GetAge();
00080     assert(time_since_birth >= 0);
00081 
00082     if (mCellProliferativeType == DIFFERENTIATED)
00083     {
00084         mCurrentCellCyclePhase = G_ZERO_PHASE;
00085     }
00086     else if ( time_since_birth < GetMDuration() )
00087     {
00088         mCurrentCellCyclePhase = M_PHASE;
00089     }
00090     else if ( time_since_birth < GetMDuration() + mG1Duration)
00091     {
00092         mCurrentCellCyclePhase = G_ONE_PHASE;
00093     }
00094     else if ( time_since_birth < GetMDuration() + mG1Duration + GetSDuration())
00095     {
00096         mCurrentCellCyclePhase = S_PHASE;
00097     }
00098     else if ( time_since_birth < GetMDuration() + mG1Duration + GetSDuration() + GetG2Duration())
00099     {
00100         mCurrentCellCyclePhase = G_TWO_PHASE;
00101     }
00102 }

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