TysonNovakCellCycleModel.hpp

00001 /*
00002 
00003 Copyright (C) University of Oxford, 2005-2010
00004 
00005 University of Oxford means the Chancellor, Masters and Scholars of the
00006 University of Oxford, having an administrative office at Wellington
00007 Square, Oxford OX1 2JD, UK.
00008 
00009 This file is part of Chaste.
00010 
00011 Chaste is free software: you can redistribute it and/or modify it
00012 under the terms of the GNU Lesser General Public License as published
00013 by the Free Software Foundation, either version 2.1 of the License, or
00014 (at your option) any later version.
00015 
00016 Chaste is distributed in the hope that it will be useful, but WITHOUT
00017 ANY WARRANTY; without even the implied warranty of MERCHANTABILITY or
00018 FITNESS FOR A PARTICULAR PURPOSE.  See the GNU Lesser General Public
00019 License for more details. The offer of Chaste under the terms of the
00020 License is subject to the License being interpreted in accordance with
00021 English Law and subject to any action against the University of Oxford
00022 being under the jurisdiction of the English Courts.
00023 
00024 You should have received a copy of the GNU Lesser General Public License
00025 along with Chaste. If not, see <http://www.gnu.org/licenses/>.
00026 
00027 */
00028 #ifndef TYSONNOVAKCELLCYCLEMODEL_HPP_
00029 #define TYSONNOVAKCELLCYCLEMODEL_HPP_
00030 
00031 #include "ChasteSerialization.hpp"
00032 
00033 #include <iostream>
00034 
00035 #include "AbstractOdeBasedCellCycleModelWithStoppingEvent.hpp"
00036 #include "TysonNovak2001OdeSystem.hpp"
00037 #include "BackwardEulerIvpOdeSolver.hpp"
00038 #include "CvodeAdaptor.hpp"
00039 #include "Exception.hpp"
00040 
00050 class TysonNovakCellCycleModel : public AbstractOdeBasedCellCycleModelWithStoppingEvent
00051 {
00052 private:
00053 
00054     friend class TestOdeBasedCellCycleModels;
00055 
00056 #ifdef CHASTE_CVODE
00057 
00058     static CvodeAdaptor msSolver;
00059 #else
00060 
00061     static BackwardEulerIvpOdeSolver msSolver;
00062 #endif  //CHASTE_CVODE
00063 
00065     friend class boost::serialization::access;
00072     template<class Archive>
00073     void serialize(Archive & archive, const unsigned int version)
00074     {
00075         archive & boost::serialization::base_object<AbstractOdeBasedCellCycleModelWithStoppingEvent>(*this);
00076     }
00077 
00078 public:
00079 
00083     TysonNovakCellCycleModel();
00084 
00092     TysonNovakCellCycleModel(const TysonNovakCellCycleModel& rOtherModel);
00093 
00098     void ResetForDivision();
00099 
00104     AbstractCellCycleModel* CreateCellCycleModel();
00105 
00112     bool SolveOdeToTime(double currentTime);
00113 
00119     double GetOdeStopTime();
00120 
00124     double GetSDuration();
00125 
00129     double GetG2Duration();
00130 
00134     double GetMDuration();
00135 
00139     void InitialiseDaughterCell();
00140 
00144     double GetAverageTransitCellCycleTime();
00145 
00149     double GetAverageStemCellCycleTime();
00150 
00154     virtual bool CanCellTerminallyDifferentiate();
00155 };
00156 
00157 
00158 #include "SerializationExportWrapper.hpp"
00159 // Declare identifier for the serializer
00160 CHASTE_CLASS_EXPORT(TysonNovakCellCycleModel)
00161 
00162 
00163 #endif /*TYSONNOVAKCELLCYCLEMODEL_HPP_*/

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