00001 /* 00002 00003 Copyright (C) University of Oxford, 2005-2010 00004 00005 University of Oxford means the Chancellor, Masters and Scholars of the 00006 University of Oxford, having an administrative office at Wellington 00007 Square, Oxford OX1 2JD, UK. 00008 00009 This file is part of Chaste. 00010 00011 Chaste is free software: you can redistribute it and/or modify it 00012 under the terms of the GNU Lesser General Public License as published 00013 by the Free Software Foundation, either version 2.1 of the License, or 00014 (at your option) any later version. 00015 00016 Chaste is distributed in the hope that it will be useful, but WITHOUT 00017 ANY WARRANTY; without even the implied warranty of MERCHANTABILITY or 00018 FITNESS FOR A PARTICULAR PURPOSE. See the GNU Lesser General Public 00019 License for more details. The offer of Chaste under the terms of the 00020 License is subject to the License being interpreted in accordance with 00021 English Law and subject to any action against the University of Oxford 00022 being under the jurisdiction of the English Courts. 00023 00024 You should have received a copy of the GNU Lesser General Public License 00025 along with Chaste. If not, see <http://www.gnu.org/licenses/>. 00026 00027 */ 00028 #include "SloughingCellKiller.hpp" 00029 #include "AbstractCellCentreBasedTissue.hpp" 00030 00031 template <unsigned DIM> 00032 SloughingCellKiller<DIM>::SloughingCellKiller(AbstractTissue<DIM>* pCrypt, bool sloughSides) 00033 : AbstractCellKiller<DIM>(pCrypt), 00034 mSloughSides(sloughSides) 00035 { 00036 } 00037 00038 template <unsigned DIM> 00039 bool SloughingCellKiller<DIM>::GetSloughSides() const 00040 { 00041 return mSloughSides; 00042 } 00043 00044 template <unsigned DIM> 00045 void SloughingCellKiller<DIM>::TestAndLabelCellsForApoptosisOrDeath() 00046 { 00047 switch (DIM) 00048 { 00049 case 1: 00050 { 00051 double crypt_length = TissueConfig::Instance()->GetCryptLength(); 00052 00053 for (typename AbstractTissue<DIM>::Iterator cell_iter = this->mpTissue->Begin(); 00054 cell_iter != this->mpTissue->End(); 00055 ++cell_iter) 00056 { 00057 double x = this->mpTissue->GetLocationOfCellCentre(*cell_iter)[0]; 00058 00059 if (x > crypt_length) 00060 { 00061 cell_iter->Kill(); 00062 } 00063 } 00064 break; 00065 } 00066 case 2: 00067 { 00068 double crypt_length = TissueConfig::Instance()->GetCryptLength(); 00069 double crypt_width = TissueConfig::Instance()->GetCryptWidth(); 00070 00071 for (typename AbstractTissue<DIM>::Iterator cell_iter = this->mpTissue->Begin(); 00072 cell_iter != this->mpTissue->End(); 00073 ++cell_iter) 00074 { 00075 c_vector<double, 2> location = this->mpTissue->GetLocationOfCellCentre(*cell_iter); 00076 double x = location[0]; 00077 double y = location[1]; 00078 00079 if ( (y>crypt_length) || (mSloughSides && ((x<0.0) || (x>crypt_width))) ) 00080 { 00081 cell_iter->Kill(); 00082 } 00083 } 00084 break; 00085 } 00086 case 3: 00087 { 00088 EXCEPTION("SloughingCellKiller is not yet implemented in 3D"); 00089 break; 00090 } 00091 default: 00092 // This can't happen 00093 NEVER_REACHED; 00094 } 00095 } 00096 00097 00099 // Explicit instantiation 00101 00102 template class SloughingCellKiller<1>; 00103 template class SloughingCellKiller<2>; 00104 template class SloughingCellKiller<3>; 00105 00106 00107 // Serialization for Boost >= 1.36 00108 #include "SerializationExportWrapperForCpp.hpp" 00109 EXPORT_TEMPLATE_CLASS_SAME_DIMS(SloughingCellKiller)