00001 /* 00002 00003 Copyright (C) University of Oxford, 2005-2010 00004 00005 University of Oxford means the Chancellor, Masters and Scholars of the 00006 University of Oxford, having an administrative office at Wellington 00007 Square, Oxford OX1 2JD, UK. 00008 00009 This file is part of Chaste. 00010 00011 Chaste is free software: you can redistribute it and/or modify it 00012 under the terms of the GNU Lesser General Public License as published 00013 by the Free Software Foundation, either version 2.1 of the License, or 00014 (at your option) any later version. 00015 00016 Chaste is distributed in the hope that it will be useful, but WITHOUT 00017 ANY WARRANTY; without even the implied warranty of MERCHANTABILITY or 00018 FITNESS FOR A PARTICULAR PURPOSE. See the GNU Lesser General Public 00019 License for more details. The offer of Chaste under the terms of the 00020 License is subject to the License being interpreted in accordance with 00021 English Law and subject to any action against the University of Oxford 00022 being under the jurisdiction of the English Courts. 00023 00024 You should have received a copy of the GNU Lesser General Public License 00025 along with Chaste. If not, see <http://www.gnu.org/licenses/>. 00026 00027 */ 00028 #ifndef SIMPLEWNTCELLCYCLEMODEL_HPP_ 00029 #define SIMPLEWNTCELLCYCLEMODEL_HPP_ 00030 00031 #include "AbstractSimpleCellCycleModel.hpp" 00032 #include "RandomNumberGenerator.hpp" 00033 #include "WntConcentration.hpp" 00034 00035 // Needed here to avoid serialization errors 00036 #include "WildTypeCellMutationState.hpp" 00037 #include "LabelledCellMutationState.hpp" 00038 #include "ApcOneHitCellMutationState.hpp" 00039 #include "ApcTwoHitCellMutationState.hpp" 00040 #include "BetaCateninOneHitCellMutationState.hpp" 00041 00042 00046 class SimpleWntCellCycleModel : public AbstractSimpleCellCycleModel 00047 { 00048 private: 00049 00051 friend class boost::serialization::access; 00058 template<class Archive> 00059 void serialize(Archive & archive, const unsigned int version) 00060 { 00061 archive & boost::serialization::base_object<AbstractSimpleCellCycleModel>(*this); 00062 00063 RandomNumberGenerator* p_gen = RandomNumberGenerator::Instance(); 00064 archive & *p_gen; 00065 00066 archive & mUseCellProliferativeTypeDependentG1Duration; 00067 } 00068 00073 bool mUseCellProliferativeTypeDependentG1Duration; 00074 00075 protected: 00076 00080 double GetWntLevel(); 00081 00086 WntConcentrationType GetWntType(); 00087 00097 void SetG1Duration(); 00098 00099 public: 00100 00105 SimpleWntCellCycleModel(); 00106 00110 virtual void UpdateCellCyclePhase(); 00111 00115 virtual void InitialiseDaughterCell(); 00116 00121 virtual AbstractCellCycleModel* CreateCellCycleModel(); 00122 00127 void SetUseCellProliferativeTypeDependentG1Duration(bool useCellProliferativeTypeDependentG1Duration=true); 00128 00132 virtual bool CanCellTerminallyDifferentiate(); 00133 }; 00134 00135 #include "SerializationExportWrapper.hpp" 00136 // Declare identifier for the serializer 00137 CHASTE_CLASS_EXPORT(SimpleWntCellCycleModel) 00138 00139 00140 namespace boost 00141 { 00142 namespace serialization 00143 { 00148 template<class Archive> 00149 inline void save_construct_data( 00150 Archive & ar, const SimpleWntCellCycleModel * t, const unsigned int file_version) 00151 { 00152 } 00153 00158 template<class Archive> 00159 inline void load_construct_data( 00160 Archive & ar, SimpleWntCellCycleModel * t, const unsigned int file_version) 00161 { 00169 ::new(t)SimpleWntCellCycleModel; 00170 } 00171 } 00172 } // namespace ... 00173 00174 #endif /*SIMPLEWNTCELLCYCLEMODEL_HPP_*/