AbstractSimpleGenerationBasedCellCycleModel.cpp

00001 /*
00002 
00003 Copyright (C) University of Oxford, 2005-2010
00004 
00005 University of Oxford means the Chancellor, Masters and Scholars of the
00006 University of Oxford, having an administrative office at Wellington
00007 Square, Oxford OX1 2JD, UK.
00008 
00009 This file is part of Chaste.
00010 
00011 Chaste is free software: you can redistribute it and/or modify it
00012 under the terms of the GNU Lesser General Public License as published
00013 by the Free Software Foundation, either version 2.1 of the License, or
00014 (at your option) any later version.
00015 
00016 Chaste is distributed in the hope that it will be useful, but WITHOUT
00017 ANY WARRANTY; without even the implied warranty of MERCHANTABILITY or
00018 FITNESS FOR A PARTICULAR PURPOSE.  See the GNU Lesser General Public
00019 License for more details. The offer of Chaste under the terms of the
00020 License is subject to the License being interpreted in accordance with
00021 English Law and subject to any action against the University of Oxford
00022 being under the jurisdiction of the English Courts.
00023 
00024 You should have received a copy of the GNU Lesser General Public License
00025 along with Chaste. If not, see <http://www.gnu.org/licenses/>.
00026 
00027 */
00028 #include "AbstractSimpleGenerationBasedCellCycleModel.hpp"
00029 
00030 
00031 AbstractSimpleGenerationBasedCellCycleModel::AbstractSimpleGenerationBasedCellCycleModel()
00032     : AbstractSimpleCellCycleModel(),
00033       mGeneration(0)
00034 {
00035 }
00036 
00037 void AbstractSimpleGenerationBasedCellCycleModel::ResetForDivision()
00038 {
00039     mGeneration++;
00040     if (mGeneration > TissueConfig::Instance()->GetMaxTransitGenerations())
00041     {
00042         mpCell->SetCellProliferativeType(DIFFERENTIATED);
00043     }
00044     if (mpCell->GetCellProliferativeType() == STEM)
00045     {
00046         mGeneration = 0;
00047     }
00048     AbstractSimpleCellCycleModel::ResetForDivision();
00049 }
00050 
00051 
00052 void AbstractSimpleGenerationBasedCellCycleModel::InitialiseDaughterCell()
00053 {
00054     /*
00055      * If the parent cell is a stem cell then its generation was reset
00056      * to zero when ResetForDivision() was called. The daughter cell's
00057      * generation must therefore be incremented here.
00058      */
00059     if (mGeneration == 0)
00060     {
00061         mGeneration = 1;
00062     }
00063     /*
00064      * In generation-based cell cycle models, the daughter cell
00065      * is always of type transit or differentiated.
00066      */
00067     mpCell->SetCellProliferativeType(TRANSIT);
00068     if (mGeneration > TissueConfig::Instance()->GetMaxTransitGenerations())
00069     {
00070         mpCell->SetCellProliferativeType(DIFFERENTIATED);
00071     }
00072     AbstractSimpleCellCycleModel::InitialiseDaughterCell();
00073 }
00074 
00075 
00076 void AbstractSimpleGenerationBasedCellCycleModel::SetGeneration(unsigned generation)
00077 {
00078     mGeneration = generation;
00079 }
00080 
00081 
00082 unsigned AbstractSimpleGenerationBasedCellCycleModel::GetGeneration() const
00083 {
00084     return mGeneration;
00085 }

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