AbstractSimpleCellCycleModel.cpp

00001 /*
00002 
00003 Copyright (C) University of Oxford, 2005-2010
00004 
00005 University of Oxford means the Chancellor, Masters and Scholars of the
00006 University of Oxford, having an administrative office at Wellington
00007 Square, Oxford OX1 2JD, UK.
00008 
00009 This file is part of Chaste.
00010 
00011 Chaste is free software: you can redistribute it and/or modify it
00012 under the terms of the GNU Lesser General Public License as published
00013 by the Free Software Foundation, either version 2.1 of the License, or
00014 (at your option) any later version.
00015 
00016 Chaste is distributed in the hope that it will be useful, but WITHOUT
00017 ANY WARRANTY; without even the implied warranty of MERCHANTABILITY or
00018 FITNESS FOR A PARTICULAR PURPOSE.  See the GNU Lesser General Public
00019 License for more details. The offer of Chaste under the terms of the
00020 License is subject to the License being interpreted in accordance with
00021 English Law and subject to any action against the University of Oxford
00022 being under the jurisdiction of the English Courts.
00023 
00024 You should have received a copy of the GNU Lesser General Public License
00025 along with Chaste. If not, see <http://www.gnu.org/licenses/>.
00026 
00027 */
00028 #include "AbstractSimpleCellCycleModel.hpp"
00029 
00030 
00031 void AbstractSimpleCellCycleModel::Initialise()
00032 {
00033     SetG1Duration();
00034 }
00035 
00036 
00037 void AbstractSimpleCellCycleModel::InitialiseDaughterCell()
00038 {
00039     AbstractCellCycleModel::InitialiseDaughterCell();
00040     SetG1Duration();
00041 }
00042 
00043 
00044 void AbstractSimpleCellCycleModel::SetG1Duration()
00045 {
00046     assert(mpCell!=NULL);
00047 
00048     switch (mpCell->GetCellProliferativeType())
00049     {
00050         case STEM:
00051             mG1Duration = TissueConfig::Instance()->GetStemCellG1Duration();
00052             break;
00053         case TRANSIT:
00054             mG1Duration = TissueConfig::Instance()->GetTransitCellG1Duration();
00055             break;
00056         case DIFFERENTIATED:
00057             mG1Duration = DBL_MAX;
00058             break;
00059         case APOPTOTIC:
00060             mG1Duration = DBL_MAX;
00061             break;
00062         default:
00063             NEVER_REACHED;
00064     }
00065 }
00066 
00067 
00068 void AbstractSimpleCellCycleModel::ResetForDivision()
00069 {
00070     AbstractCellCycleModel::ResetForDivision();
00071     mBirthTime = SimulationTime::Instance()->GetTime();
00072     SetG1Duration();
00073 }
00074 
00075 
00076 void AbstractSimpleCellCycleModel::UpdateCellCyclePhase()
00077 {
00078     double time_since_birth = GetAge();
00079     assert(time_since_birth >= 0);
00080 
00081     if (mpCell->GetCellProliferativeType()==DIFFERENTIATED)
00082     {
00083         mCurrentCellCyclePhase = G_ZERO_PHASE;
00084     }
00085     else if ( time_since_birth < GetMDuration() )
00086     {
00087         mCurrentCellCyclePhase = M_PHASE;
00088     }
00089     else if ( time_since_birth < GetMDuration() + mG1Duration)
00090     {
00091         mCurrentCellCyclePhase = G_ONE_PHASE;
00092     }
00093     else if ( time_since_birth < GetMDuration() + mG1Duration + GetSDuration())
00094     {
00095         mCurrentCellCyclePhase = S_PHASE;
00096     }
00097     else if ( time_since_birth < GetMDuration() + mG1Duration + GetSDuration() + GetG2Duration())
00098     {
00099         mCurrentCellCyclePhase = G_TWO_PHASE;
00100     }
00101 }

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