LuoRudyIModel1991OdeSystem.hpp

/*

Copyright (C) University of Oxford, 2005-2009

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This file is part of Chaste.

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under the terms of the GNU Lesser General Public License as published
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(at your option) any later version.

Chaste is distributed in the hope that it will be useful, but WITHOUT
ANY WARRANTY; without even the implied warranty of MERCHANTABILITY or
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License for more details. The offer of Chaste under the terms of the
License is subject to the License being interpreted in accordance with
English Law and subject to any action against the University of Oxford
being under the jurisdiction of the English Courts.

You should have received a copy of the GNU Lesser General Public License
along with Chaste. If not, see <http://www.gnu.org/licenses/>.

*/
#ifndef _LUORUDYIMODEL1991ODESYSTEM_HPP_
#define _LUORUDYIMODEL1991ODESYSTEM_HPP_

#include "AbstractCardiacCell.hpp"
#include "AbstractStimulusFunction.hpp"
#include <vector>

class LuoRudyIModel1991OdeSystem : public AbstractCardiacCell
{
private:

    static const double membrane_C = 1.0;
    static const double membrane_F = 96484.6;
    static const double membrane_R = 8314;
    static const double membrane_T = 310.0;
    static const double background_current_E_b = -59.87;
    static const double background_current_g_b = 0.03921;
    static const double fast_sodium_current_g_Na = 23.0;
    static const double ionic_concentrations_Ki = 145.0;
    static const double ionic_concentrations_Ko = 5.4;
    static const double ionic_concentrations_Nai = 18.0;
    static const double ionic_concentrations_Nao = 140.0;
    static const double plateau_potassium_current_g_Kp = 0.0183;
    static const double time_dependent_potassium_current_PR_NaK = 0.01833;

    double fast_sodium_current_E_Na;

    void VerifyStateVariables();
    
public:
    // Constructor
    LuoRudyIModel1991OdeSystem(AbstractIvpOdeSolver *pSolver,
                               AbstractStimulusFunction *pIntracellularStimulus);
                               
    // Destructor
    ~LuoRudyIModel1991OdeSystem();
        
    // This method will compute the RHS of the LuoRudyIModel1991OdeSystem model
    void EvaluateYDerivatives(double time, const std::vector<double> &rY, std::vector<double> &rDY);
    
    double GetIIonic();
    
    double GetIntracellularCalciumConcentration();
};

#endif // _LUORUDYIMODEL1991ODESYSTEM_HPP_

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