AbstractCellsGenerator.hpp

00001 /*
00002 
00003 Copyright (C) University of Oxford, 2005-2009
00004 
00005 University of Oxford means the Chancellor, Masters and Scholars of the
00006 University of Oxford, having an administrative office at Wellington
00007 Square, Oxford OX1 2JD, UK.
00008 
00009 This file is part of Chaste.
00010 
00011 Chaste is free software: you can redistribute it and/or modify it
00012 under the terms of the GNU Lesser General Public License as published
00013 by the Free Software Foundation, either version 2.1 of the License, or
00014 (at your option) any later version.
00015 
00016 Chaste is distributed in the hope that it will be useful, but WITHOUT
00017 ANY WARRANTY; without even the implied warranty of MERCHANTABILITY or
00018 FITNESS FOR A PARTICULAR PURPOSE.  See the GNU Lesser General Public
00019 License for more details. The offer of Chaste under the terms of the
00020 License is subject to the License being interpreted in accordance with
00021 English Law and subject to any action against the University of Oxford
00022 being under the jurisdiction of the English Courts.
00023 
00024 You should have received a copy of the GNU Lesser General Public License
00025 along with Chaste. If not, see <http://www.gnu.org/licenses/>.
00026 
00027 */
00028 #ifndef ABSTRACTCELLSGENERATOR_HPP_
00029 #define ABSTRACTCELLSGENERATOR_HPP_
00030 
00031 #include "TetrahedralMesh.hpp"
00032 #include "TissueCell.hpp"
00033 #include "AbstractSimpleGenerationBasedCellCycleModel.hpp"
00034 #include "RandomNumberGenerator.hpp"
00035 
00036 
00042 template<unsigned DIM>
00043 class AbstractCellsGenerator
00044 {
00045 public:
00046 
00050     AbstractCellsGenerator()
00051     {}
00052 
00056     virtual AbstractCellCycleModel* CreateCellCycleModel()=0;
00057 
00063     virtual double GetTypicalTransitCellCycleTime()=0;
00064 
00070     virtual double GetTypicalStemCellCycleTime()=0;
00071 
00076     virtual bool CellsCanDifferentiate();
00077 
00081     virtual ~AbstractCellsGenerator()
00082     {}
00083 
00092     void GenerateBasic(std::vector<TissueCell>& rCells,
00093                        const unsigned numCells);
00094 
00113     virtual void GenerateForCrypt(std::vector<TissueCell>& rCells,
00114                                   TetrahedralMesh<2,2>& rMesh,
00115                                   const std::vector<unsigned> locationIndices,
00116                                   bool randomBirthTimes,
00117                                   double y0 = 0.3,
00118                                   double y1 = 2.0,
00119                                   double y2 = 3.0,
00120                                   double y3 = 4.0,
00121                                   bool initialiseCells = false);
00122 };
00123 
00124 
00125 
00126 #endif /*ABSTRACTCELLSGENERATOR_HPP_*/

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