The box below shows what is available to download. To download a file, please fill in the form below and select the appropriate file from the drop-down menu.

chaste_release_2021_1.html - 399B
Instructions for obtaining the latest source code from GitHub
Ubuntu_package.html - 609B
Instructions for connecting an Ubuntu machine to the Chaste source and dependency packages for ease of installation
chaste_release_2019_1.html - 404B
(Instructions for obtaining the latest source code from GitHub)
chaste_release_2018_1.html - 403B
(Instructions for obtaining the latest source code from GitHub)
chaste_release_2017_1.html - 501B
(Instructions for obtaining the latest source code from GitHub)
StandaloneChaste_release_3_4_64bit.tgz - 47.55MB
Cardiac Chaste standalone binary with minimal XML input. [We can no longer support precompiled standalone binaries after 3.4. Version 3.4 was compiled on 12.04 and tested on 14.04 but will not run on 16.04.]
chaste_release_3_4.tgz - 116.36MB
This is the main source code release and includes PyCml
StandaloneChaste_release_3_3_64bit.tgz - 32.21MB
Cardiac Chaste standalone binary with minimal XML input, v3.3
chaste_release_3_3.tgz - 106.08MB
This is the main source code release and includes PyCml, v3.3
StandaloneChaste_release_3_2_64bit.tgz - 32.02MB
Cardiac Chaste standalone binary with minimal XML input, v3.2
chaste_release_3_2.tgz - 106.22MB
This is the main source code release and includes PyCml, v3.2
StandaloneChaste_release_3_1_32bit.tgz - 21.01MB
Cardiac Chaste standalone binary with minimal XML input, v3.1
StandaloneChaste_release_3_1_64bit.tgz - 16.67MB
Cardiac Chaste standalone binary with minimal XML input, v3.1
chaste_release_3_1.tgz - 118.93MB
This is the main source code release and includes PyCml, v3.1
StandaloneChaste_release_3_0_32bit.tgz - 19.44MB
Cardiac Chaste standalone binary with minimal XML input, v3.0
StandaloneChaste_release_3_0_64bit.tgz - 29.27MB
Cardiac Chaste standalone binary with minimal XML input, v3.0
chaste_release_3_0.tgz - 115.71MB
This is the main source code release and includes PyCml, v3.0
StandaloneChaste_release_2_3_32bit.tgz - 18.69MB
Cardiac Chaste standalone binary with minimal XML input, v2.3
StandaloneChaste_release_2_3_64bit.tgz - 15.37MB
Cardiac Chaste standalone binary with minimal XML input, v2.3
chaste_release_2_3.tgz - 85.31MB
This is the main source code release and includes PyCml, v2.3
StandaloneChaste_release_2_2_32bit.tgz - 18.34MB
Cardiac Chaste standalone binary with minimal XML input, v2.2
StandaloneChaste_release_2_2_64bit.tgz - 19.66MB
Cardiac Chaste standalone binary with minimal XML input, v2.2
chaste_release_2_2.tgz - 117.97MB
This is the main source code release and includes PyCml, v2.2
StandaloneChaste_release_2_1_32bit.tgz - 17.21MB
Cardiac Chaste standalone binary with minimal XML input, v2.1
StandaloneChaste_release_2_1_64bit.tgz - 18.72MB
Cardiac Chaste standalone binary with minimal XML input, v2.1
chaste_release_2_1.tgz - 72.97MB
This is the main source code release and includes PyCml, v2.1
StandaloneChaste_release_2_0_32bit.tgz - 5.82MB
Cardiac Chaste standalone binary with minimal XML input, v2.0
StandaloneChaste_release_2_0_64bit.tgz - 6.72MB
Cardiac Chaste standalone binary with minimal XML input, v2.0
chaste_release_2_0.tgz - 60.94MB
This is the main source code release and includes PyCml, v2.0
StandaloneChaste_release_1_1_32bit.tgz - 4.41MB
Cardiac Chaste standalone binary with minimal XML input, v1.1
StandaloneChaste_release_1_1_64bit.tgz - 5.15MB
Cardiac Chaste standalone binary with minimal XML input, v1.1
chaste_release_1_1.tgz - 40.06MB
This is the main source code release and now includes PyCml, v1.1
StandaloneChaste_release_1_32bit.tgz - 3.97MB
Cardiac Chaste standalone binary with minimal XML input, v1.0
StandaloneChaste_release_1_64bit.tgz - 4.78MB
Cardiac Chaste standalone binary with minimal XML input, v1.0
chaste_release_1.tgz - 85MB
This is the main source code release, v1.0
pycml_release_1.tgz - 151.48kB
Associated release of PyCml CellML tools in Python. Note that from Chaste release 1.1 onwards this is bundled with the main source release.
CaDiffusion_release_3_4.tgz - 21.87MB
Code for reproducing the calcium diffusion simulations featured in Samanta et al. "Ca2+ Channel Re-localization to Plasma-Membrane Microdomains Strengthens Activation of Ca2+-Dependent Nuclear Gene Expression". Cell Reports (2015). Bolt-on project for release 3.4
ApPredict_release_3_4.tgz - 2.88MB
Code for predicting changes to action potentials under conductance block of ion channels, basis of ActionPotential web portal simulations. Bolt-on project for release 3.4.
ApPredict_release_3_3.tgz - 2.79MB
Code for predicting changes to action potentials under conductance block of ion channels, basis of ActionPotential web portal simulations. Bolt-on project for release 3.3.
Jmcc_UQ_release_3_3.tgz - 8.02MB
Code associated with Johnstone et al. (submitted). Bolt-on project for release 3.3
MouseLesion_release_3_3.tgz - 207.12MB
Code associated with Mahoney et al. "Connexin 43 contributes to electrotonic conduction across scar tissue in the intact heart" Scientific Reports, 2016. See the tutorial. Bolt-on project for release 3.3
HR2015_release_3_3.tgz - 67.38kB
Code associated with Capel et al. "Hydroxychloroquine reduces heart rate by modulating the hyperpolarisation activated current If " Heart Rhythm (2015). See the tutorial. Bolt-on project for release 3.3
StochasticPhenomenologicalModels_release_3_3.tgz - 34.76MB
Code associated with Walmsley et al. "Application of stochastic phenomenological modelling to cell-to-cell and beat-to-beat electrophysiological variability in cardiac tissue"; Journal of Theoretical Biology, 2015. Bolt-on project for Release 3.3
Frontiers2014_release_3_3.tgz - 152.5MB
Code associated with Cooper et al. "Cellular cardiac electrophysiology modelling with Chaste and CellML" Frontiers in Physiology, 2015. Bolt-on project for Release 3.3.
FunctionalCuration_release_3.2.tgz - 12.65MB
Back-end code for the Cardiac Electrophsyiology Web Lab as a bolt-on project for release 3.2. See also the introductory page on the Chaste wiki.
Jptm2014_release_3_2.tgz - 58.85MB
Code associated with Mirams et al. "Prediction of Thorough QT study results using action potential models based on ion channel screening data" Submitted to Journal of Pharmacological and Toxicological Methods. Bolt on project for release 3.2.
ApPredict_release_3_2.tgz - 2.47MB
Code for predicting changes to action potentials under conductance block of ion channels, basis of ActionPotential web portal simulations. Bolt-on project for release 3.2.
Wisc2013_release_3.2.tgz - 31.12kB
Code associated with Cooper & Osborne "Connecting models to data in multiscale multicellular tissue simulations" ICCS2013. See the tutorial for more information. Bolt on project for release 3.2.
STI-GMaS_v1.2_release3.1_Win64.zip - 27.02MB
Windows binary for the University of Nottingham sexually transmitted infection modelling tool (STI-GMaS Homepage).
STI-GMaS_v1.2_release3.1_Linux.tgz - 363.22kB
Linux mixed binary & source for the University of Nottingham sexually transmitted infection modelling tool (STI-GMaS Homepage).
STI-GMaS_v1.1_release_3.1.tgz - 237.53kB
Code for the University of Nottingham sexually transmitted infection modelling tool (STI-GMaS Homepage). Bolt-on project for release 3.1.
Jptm2013Elkins_release_3_1.tgz - 12.31MB
Code associated with Elkins et al. "Variability in high-throughput ion-channel screening data and consequences for cardiac safety assessment" Journal of Pharmacological and Toxicological Methods, 2013. Bolt-on project for release 3.1.
Jptm2013Beattie_revision_18049.tgz - 295.26kB
Code associated with Beattie et al. "Evaluation of an In Silico Cardiac Safety Assay: Using Ion Channel Screening Data to Predict QT Interval Changes in the Rabbit Ventricular Wedge." Journal of Pharmacological and Toxicological Methods, 2013. Bolt-on project for revision 18049 only.
PlosOne_mRNA_release_3.1.tgz - 26.66MB
Code associated with Walmsley et al. "mRNA Expression Levels in Failing Human Hearts Predict Cellular Electrophysiological Remodeling: A Population-Based Simulation Study" PLoS ONE, 2013. Bolt-on project for release 3.1.
Plos2013_release_3.1.tgz - 41.04MB
Code associated with Mirams et al. "Chaste: a C++ library for computational physiology and biology" PLoS Computational Biology, 2013. Bolt-on project for release 3.1.
Plos2013_release_3.3.tgz - 41.04MB
Code associated with Mirams et al. "Chaste: a C++ library for computational physiology and biology" PLoS Computational Biology, 2013. Updated bolt-on project for release 3.3.
CryptInvasion_release_3.0.tgz - 8.05MB
Code associated with Mirams et al. "A theoretical investigation of the effect of proliferation and adhesion on monoclonal conversion in the colonic crypt" (J Theor Biol, 2012) Bolt-on project for release 3.0
ChasteMembrane_1.0_release_2_0.tgz - 10.33MB
Code associated with Agudelo-Toro and Neef. "Computationally efficient simulation of electrical activity at cell membranes interacting with self-generated and externally imposed electric fields " ( J. Neural Eng.,2013) Bolt-on project for release 2.0
Requires Chaste 2.0, PETSc 3.0 and Boost >= 1.36. Further details of pre-requisites and configuration are in README.txt within download.
FunctionalCuration_release_3.0.tgz - 940.74kB
Code associated with Cooper et al. "High throughput functional curation of cellular electrophysiology models" (Prog. Biophys. Mol. Biol., 2011) Bolt-on project for release 3.0
See also the introductory page on the Chaste wiki.
CardiovascRes11_project_release_2_1.tgz - 41.48MB
Data and models associated with Mirams et al. "Simulation of multiple ion channel block provides improved early prediction of compounds' clinical torsadogenic risk" (Cardiovascular Research, 2011) Bolt-on project for release 2.1
PhilTransA2009_release_1_1.tgz - 49.61kB
Code and algorithms associated with Bernabeu et al. "Chaste: Incorporating a novel multi-scale spatial and temporal algorithm..." (Phil. Trans. R. Soc. A, 2009) Bolt-on project for release 1.1
CellProliferation09_project_release_1.tgz - 166.81MB
Data and models associated with van Leeuwen et al. "An Integrative Computational Model for Intestinal Tissue Renewal" (Cell Proliferation, 2009) Bolt-on project for release 1
VertexComparison2013_release3.3.tgz - 22.54kB
Code associated with Fletcher et al. "Implementing vertex dynamics models of cell populations in biology within a consistent computational framework" Prog. Biophys. Mol. Biol. (2013). Updated bolt-on project for release 3.3.
Files suitable for use with Chaste 3.1 and below only. See the Chaste data repository for files compatible with releases 3.2 and newer.
OxfordRabbitHeart_binary_3.1.tgz - 373.56MB
4 million node rabbit ventricular tetrahedral mesh (in this case without perfusing bath) reconstructed from MRI data, in a binary format suitable for Chaste 3.1 and below. See Bishop et al. "Development of an anatomically detailed MRI-derived rabbit ventricular model..." (Am J Physiol Heart Circ Physiol, 2010).
OxfordRabbitHeartWithBath_binary_3.1.tgz - 476.23MB
Rabbit ventricular tetrahedral mesh (reconstructed from MRI data), in this case with surrounding cuboid-shaped perfusing bath, in a binary format suitable for Chaste 3.1 and below. See Bishop et al. "Development of an anatomically detailed MRI-derived rabbit ventricular model..." (Am J Physiol Heart Circ Physiol, 2010).
Related data
OxfordRabbitMRData.tar.gz - 3.38GB
Raw high-resolution MR data set of rabbit heart (2048 x 1024x1024 tif files). See Bishop et al. "Development of an anatomically detailed MRI-derived rabbit ventricular model..." (Am J Physiol Heart Circ Physiol, 2010)
MidOxfordRabbitHeartPurkinjeNoBath.tgz - 61.38MB
Mid-resolution rabbit ventricular tetrahedral mesh incorporating specialized conduction system (without perfusing bath). See Bordas et al. "Rabbit-Specific Ventricular Model of Cardiac Electrophysiological Function including Specialized Conduction System." (Prog Biophys Mol Bio, 2011).
MidOxfordRabbitHeartPurkinjeBath.tgz - 91.11MB
Mid-resolution rabbit ventricular tetrahedral mesh incorporating specialized conduction system (with perfusing bath). See Bordas et al. "Rabbit-Specific Ventricular Model of Cardiac Electrophysiological Function including Specialized Conduction System." (Prog Biophys Mol Bio, 2011).
ChasteLungImpedance_v1_64bit.tgz - 37.74MB
A demonstration AirPROM standalone executable
Meshalyzer

The Meshalyzer manual is also available from the Chaste developers' wiki.

Meshalyzer32Bit.tar.gz - 583.95kB
Binary for Ed Vigmond's cardiac visualization program Meshalyzer. (You will need to have FLTK (1.1) libraries installed)
Meshalyzer64Bit.tar.gz - 676.71kB
Binary for Ed Vigmond's cardiac visualization program Meshalyzer. (You will need to have FLTK (1.1) libraries installed)
MeshalyzerTestDataset.tar.gz - 46.34MB
Sample data for Meshalyzer
Optional library dependencies
libadaptivity.tgz - 6.52MB
Sequential mesh adaptivity library from Imperial College London
libparallel_adaptivity.tgz - 644.17kB
Prototype parallel mesh adaptivity library developed by FLE and ICL
CardioELSE

The CardioELSE code is based on a spectral-element technique developed to solve the bidomain equations on unstructured all hexahedral grids. It is aimed at identifying advantages and drawbacks of spectral elements with respect to traditional finite elements, in terms of flexibility (capability to deal with realistic 3D heart models), accuracy and performance (execution-time and memory allocation). It is thus not as flexible or general purpose as Chaste.

CardioELSE was developed by a team mainly from the Bioinformatics Laboratory at CRS4, funded as part of the preDiCT FP7 project, and is released under the LGPL 3.0 licence as "citeware". The following references are appropriate:

  • Fabio Maggio, James Southern, Giorgio Fotia, and Gianmauro Cuccuru. A 3D Spectral Element Solver for the Bidomain Equations. Poster presented at the VPH 2010 Annual Conference 30 September - 1 October 2010 Brussels, Belgium, Sept 2010.
  • Fabio Maggio, Bruno Carpentieri, and Giorgio Fotia. Spectral Elements Applied to Cardiac Simulation: a Comparison with Finite Elements. Technical Report 09/51. CRS4, Center for Advanced Studies, Research and Development in Sardinia. Cagliari, Italy, Sept 2009.
  • Fabio Maggio, Bruno Carpentieri, and Giorgio Fotia. A 3D Solver for the Bidomain Equations Based on Unstructured All-hexahedra Spectral Elements. Technical Report 09/50. CRS4, Center for Advanced Studies, Research and Development in Sardinia. Cagliari, Italy, Aug 2009.
CardioELSE_V1.0.tar.gz - 4MB
CardioELSE source code
CardioELSE_manual.pdf - 162.28kB
CardioELSE manual
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Notes

We would very much appreciate it if you were to acknowledge your use of Chaste whenever possible (for publications, you may want to refer to our current Chaste publications).