ActionPotential-Portal application

This web portal provides a user-interface, results database and results presentation for the 'Action Potential Prediction' (ApPredict) open source cardiac electrophysiology simulator, for changes to the action potential under drug block of multiple ion channels.
It allows you to enter information on multiple cardiac ion channel block by a compound, and to predict the effect on whole cardiac myocyte electrophysiology, across a range of concentrations, as shown below:

This particular version is a redevelopment of the original portal, and it has been designed to run in a series of docker containers, which provides a convenient way to install a local instance. See instructions on github for more details.
We are inviting users to register their interest by registering for an account. For information about privacy and security see our privacy policy. Any queries or feedback you may have for us will be gratefully received, please contact the team to let us know.

Flowchart of information from ion channel screening informing action potential models.

A full guide to (an earlier version of) this web portal has been uploaded to Figshare : A guide to the Action Potential Prediction 'AP-Portal' web portal (pdf).
Journal of Pharmacological and Toxicological Methods article : A web portal for in-silico action potential predictions.
The underlying ApPredict software is available as open source software on github. The portal software itself is also open source and can also be found on: github.

Development of this web portal was funded under a Mathematics in Toxicology Strategic Award (NC/K001337/1) to Dr Gary Mirams, by the EPSRC and NC3Rs:

Engineering and Physical Sciences Research Council logo National Centre for the Replacement, Refinement & Reduction of Animals in Research logo